🧬 Regulatory Key Fertility Predictor

Methodology — Open Source

This tool uses 22-mer regulatory key profiling (Tobul, 2026). Each genome is scanned blindly for its most frequent 22-base sequences. These are the transposon core — the regulatory fingerprint of the species.

Two species are compared by counting how many of their top 1,000 regulatory keys are shared. The overlap predicts reproductive compatibility:

• ≥900/1000 + same Key #1: Fertile hybrid (identical regulatory center)
• ≥900/1000 + different Key #1: Difficult — high overlap but different center (e.g., Water Buffalo × Cow)
• 700–899: Sterile hybrid possible (shared keys, different centers)
• 300–699: Extremely rare, mostly sterile
• ≥500: Theoretical only — never observed in nature
• <500: Impossible — insufficient shared regulatory platform

Tool: genome_profiler_v5 — two-pass Count-Min Sketch, 49 seconds per genome, 4.5GB RAM. Code available upon request.

Database: 22 species profiled (17 non-primates + 5 primates). Validation against known hybrids: 7/9 correct predictions.

Primate finding: Human and Orangutan share identical Key #1 (Alu element core). Chimpanzee and Bonobo share a different Key #1. Gorilla has a unique key with 2M copies — the highest of any primate.

boundbydesign.org · Eran Tobul, 2026